arcgis desktop - Using Data Driven Pages (DDP) to create set of maps with same extent but different layers?

Is it possible to utilise the Data Driven Pages (DDP) tool in ArcMap or ArcPy to create a set of maps with the same extent but showing different layers?

To clarify I regularly make large sets of maps for projects all in the same location often with the same baselayers but modified to focus on different aspects for the relevant section of a report such as monitoring locations, land-use, key features etc. which all require separate .mxds to be created and maintained.

A DDP type system would allow me to utilise the dynamic text and ensure a standard template / output throughout, it would also make life a lot easier when updating a general figure number or comment as a report is written in one .mxd rather than multiple for a client.

I'm using ArcMap 10.1, but having read through the ArcGIS DDP online help I assume this would have to be done with ArcPy as I've been unable to figure out how to do it within ArcMap. I'm aware that QGIS has the Atlas Plugin, although I'm not as familiar with its capabilities but would happily use it as an alternative.

Answer

Here's my thinking in pseudocode: you'd get your MapDocument, then ListDataFrames, then ListLayers. Then you should be able to iterate through the Layers, toggle the Layer's Visibility property on, ExportToPDF (or whatever), then toggle Visibility off again, and move on to the next Layer. If you want to leave certain layers on as base layers, maybe you could group the ones you want to change for each map and only toggle visibility for those by testing for IsGroupLayer=True? Maybe someone else has an actual code example...