qgis - Geopackage: update query generates an error "no such function: ST_IsEmpty"

I created a geopackage using QGIS 2.18.3 and it works fine with QGIS. I am using SQLiteStudio 3.1.1 to add check constraints and again, the geopackage has been working fine. However, if I try to execute an update query that sets a single column to NULL (update ParkTrees set system_id = null) using SQLiteStudio I get this error:

[07:33:14] Error while executing SQL query on database 'ParkTreesFileSpec': no such function: ST_IsEmpty

How do I edit data in geopackage created by QGIS without using QGIS?