arcpy - Automating Select by Location in ArcGIS Desktop?

I have 2 shapefiles (A and B) each with thousands of polygons. I want to select polygons from A which intersect a specific polygon from B, and save the selected polygons from A as a new shapefile.

I can do this using the 'select by location' feature and 'create layer from selected features'.

However, I want to repeat this for every single polygon in B.

Is it possible to automate such a task? I don't know Python, but may be able to have somebody do this for me if that is the best method.