Can ogr2ogr "reverse clip" (or "clip out" or "erase" or "difference") one shapefile from another?

Is there a means in ogr2ogr to "clip out" one shapefile from another?

I know ogr2ogr -clipsrc B.shp out.shp A.shp will remove any part of A.shp that is NOT in B.shp.

Is there an ogr2ogr command to remove any part of A.shp that intersects with B.shp?

I have seen this called "reverse clip", "clip out", "erase" (ArcMap), or "difference".

Note: this question is about ogr2ogr, the command line tool, NOT the OGR library, which requires programming.